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., 1997). It was verified that this outcome was mediated throughout the CB1 receptor and occurred in a dose that was not connected with obvious side effects. This review also demonstrated a rise in thermal hyperalgesia and mechanical allodynia by administration of SR141716a on your own, main the authors to infer the presence of the endogenous tone of cannabinoid analgesia in neuropathy. Even so, the evidence for these kinds of tone throughout inflammation is controversial (Beaulieu et al